Research Engineer - High-throughput assay development

At Adaptyv, our high-throughput cloud lab enables protein designers to experimentally validate their proteins with the click of a button. We're building advanced molecular biology workflows, assay automation and software infrastructure to make it easy for our users to engineer better proteins. Since the launch of our beta access in June 2024 we've been growing rapidly and are now working with the fastest-moving protein design teams in the world , across tech bio startups, major AI companies and the biggest pharmas.

About the role

We are looking for a Research Engineer to join our Biology Team, specializing in high-throughput assay development for in vitro protein characterization, biophysical assays, and cell-based assays. You will be responsible for designing, optimizing, and automating scalable screening methods to accelerate protein engineering, functional validation, and biophysical analysis in our highly automated Foundry.

Responsibilities

• Develop and optimize high-throughput in vitro protein characterization assays, including binding, stability, solubility, and enzymatic activity assays.

• Design and automate cell-based assays for functional protein characterization, including reporter assays, cell surface binding, internalization assays, and proliferation or signaling assays.

• Automate assay workflows using liquid handlers, robotic platforms, and microfluidics to scale up experimental throughput and reproducibility.

• Develop multiplexed and miniaturized screening approaches, integrating NGS-based functional screening and microfluidic-based selection for protein engineering applications.

• Work closely with the Software and ML Teams to integrate assay data into computational pipelines for real-time analysis and predictive modeling.

• Analyze and interpret large datasets, applying statistical methods and machine learning to extract biological insights.

• Optimize assays for library screening and directed evolution, supporting protein optimization efforts with high-throughput functional readouts.

Qualifications

• BS, MS, or PhD in Biotechnology, Bioengineering, Biophysics, Chemical Biology, or a related field.

• At least 2 years of hands-on experience developing and running biochemical, biophysical, or cell-based assays.

• Experience with lab automation equipment, including liquid handlers, robotic arms, and microfluidics for high-throughput screening.

• Proficiency in Python for data analysis, automation integration, and assay design.

• Strong background in protein characterization techniques, including binding kinetics, stability profiling, enzymatic activity measurements, and cellular functional assays.

• Familiarity with cell culture techniques for eukaryotic and prokaryotic systems and assay development for high-throughput screening platforms.

• Ability to work in a fast-paced startup environment, solve complex problems, and drive technological innovation in assay development.

Application deadline

We are reviewing applicants on a rolling basis.