Olio Labs - Combination therapeutics for the world's toughest diseases
Using AI to design better treatments for disease
In short
Olio labs uses AI to develop combination therapeutics that consider the thousands of interacting proteins in your body rather than targeting just one or two.
The problem
Drug discovery focuses on finding therapeutics that target one or two proteins. But proteins are found in many organs throughout the body, which results in side effects.
Combinations of therapeutics allow for better targeting in the right places.
Optimizing a combination requires testing trillions of combinations, which is impossible in vitro (cell culture) or in vivo (rodents).
Solution
We have developed a computational platform that allows rapid in silico testing to find only the most promising combinations to move forward.
We have lead combinations that beat the currently available market-leading drugs.
Who are we?
David and Tom are both systems neuroscientists and worked together on the Computational Biology team at Loyal for Dogs.
In our PhDs we used research tools that allowed single neurons to be turned on or off in order to test their function. These tools are not available in humans, but is there another way to be this precise? Combinations of therapeutics make it possible.
We are a new type of scientist that has emerged over the past decade - as comfortable working at the bench as we are in the codebase. This means we have a full understanding of the problems and tools, from cell to model, with no disconnect between engineers and scientists. We are looking to automate every aspect of the drug discovery and development process and expand our platform into multiple indications.
Get in touch with us if you can help us find:
- Connections in mid to large pharmaceutical companies.
- Leads on any developing molecules you find interesting that we can test out in our models.
- Builders in the AI x Bio space who might resonate with our mission.
… or if you just want to learn more!