tl;dr - Volta Labs introduces Callisto, a groundbreaking genomics sample preparation system. With its push-button simplicity, Callisto transforms sample prep unlike anything else in the past 15 years, offering a revolutionary and hands-free experience. Checkout the product here.
Volta Labs is a group of antidisciplinary scientists and builders working at the intersection of engineering and biology. With the release of Callisto, we brought to life a sequencer agnostic platform that spans from the raw biological sample to sequenceable molecules. We have done this by reinventing the full stack — hardware, software, chemistry, and biology. At Volta, we’re not just shaping the future of genomics, we are engineering it.
🤔 The Problem
Genomic sequencing has made remarkable strides since its inception in 1990, with continuous advancements in both sequencing and data analysis over the past three decades. However, the process of preparing samples for sequencing has seen limited innovation during this time. Despite the tremendous progress in sequencing technologies, the sample preparation phase remains a bottleneck, often taking multiple days and requiring skilled lab technicians and expensive instruments.
✅ The Solution - The CallistoTM Sample Prep System
At Volta, we aim to reduce time and complexity with the introduction of our flagship product, Callisto – a benchtop instrument with many pre-optimized applications that reduces operational requirements and costs in the laboratory and clinic that were previously cost-prohibitive. This innovation addresses the longstanding challenges that have hindered efficiency and accessibility in genomics, making it a game-changer for the industry.
✨ Benefits
Callisto is set to revolutionize laboratories, seamlessly combining efficient nucleic acid extraction with push-button library creation. Explore some of the many advantages that Callisto introduces to the field of genomics sequencing:
🤝 Our Ask
In 2018, Volta Labs was born in the halls of MIT with a clear mission: to unlock the utility of genomics for the world.\Previously nestled in the vibrant hub of Kendall Square, known as "the most innovative square mile on the planet," we quickly became immersed in the dynamic biotech culture. After numerous conversations with other scientists and hours of research, we discovered that trailblazing biologists were being held back by the constraints of existing automation tools, particularly in the realm of DNA sequencing. While DNA readout technologies surged ahead, the upstream steps of sample preparation (sample prep) lagged behind.\During Founder Udayan Umapathi’s graduate stint at the MIT Media Lab, what began as a humble printed circuit board to manipulate colorful droplets soon evolved into a solutionfor the notorious "sample prep bottleneck." Propelled into action, we secured funding from top-tier VCs and got to work.
Since the company was funded coming our YC in Winter 2019, our focus has been laser-sharp in the lab, where we've been busy inventing and constructing groundbreaking fluidic and sample manipulation technologies. We embrace an anti-disciplinary approach, tackling the toughest challenges by seamlessly integrating instrumentation, fluidics, software, biology, and chemistry. While we're currently channelling our energies into sequencing sample prep, our grand vision extends beyond – envisioning a future where a single universal machine automates the lion's share of biological workflows in genomics, proteomics, and synthetic biology.\At Volta, we're not just shaping the future of genomics; we're engineering it. Join us in harnessing the power of biology and technology to change the world.
We are in the midst of a genomic revolution. From 1999 to 2000, the Human Genome Project generated the first “draft” human genome, which cost ~$300 million across 20 labs worldwide. It took another three years, and hundreds of millions of dollars, to produce a human genome that was ~90% complete, as complete as the technologies for sequencing DNA allowed at the time. In 2023, a scientist can sequence a genome at a bench for hundreds of dollars in a day. The adoption of sequencing technologies across new applications only continues to accelerate as it becomes easier, faster, and cheaper. \Despite these advancements, preparing samples for sequencing remains a significant bottleneck. We believe that disruptive innovations are needed in sample prep to unlock the true utility of genomics. With the new reality of the $200 genome (sequencing cost alone), sample prep is becoming a more significant burden on labs than ever before.
We build Integrated circuits for biology workflows
A high throughput automation system for Next-Generation Sequencing (NGS) sample preparation using digital microfluidic chip technology.