B2B Software and Services Startups funded by Y Combinator (YC) in Boston 2025

December 2025

Browse 22 of the top B2B Software and Services startups funded by Y Combinator. Headquartered in Boston, these are some of the hottest and fastest-growing startups. This doesn't include all companies originally founded in Boston or by founders from there.

We also have a Startup Directory where you can search through over 5,000 companies.

  • Expected Parrot
    Expected Parrot
    Y Combinator LogoF2025
    Active • 5 employees • Cambridge, MA, USA
    Expected Parrot helps companies simulate their customers with AI agents to explore pricing, product, marketing, communications and other scenarios at scale. Our open-source library and no-code web app let you design custom agent personas and conduct interviews and surveys with them using LLMs of your choice to generate results and reports. Everything is cached and reproducible, and you can send the same surveys to human respondents to validate results in the same interface.
    generative-ai
    saas
    open-source
  • Blueshoe
    Blueshoe
    Y Combinator LogoX2025
    Active • 2 employees • Boston, MA, USA
    Blueshoe is an AI platform for legal research and reasoning designed to capture the structure of legal thought and allow users to work directly within the logic of caselaw. By combining advanced AI with curated legal and proprietary data pipelines, the system allows users build and test arguments with unprecedented clarity.
    generative-ai
    legal
    legaltech
  • Delineate
    Delineate
    Y Combinator LogoW2025
    Active • 20 employees • Boston, MA, USA
    Delineate is building AI agents to design better clinical trials faster. This is a $10B dollar market, where saving even 1 day along the process is equal to $1-5M in revenue potential. We process existing clinical trial research into specialized datasets saving scientists months of effort. Delineate is working with two of the largest pharmaceutical companies. With one of our customers, we are helping them get to the next phase of trials faster by creating the largest dataset on a drug class ever constructed.
    saas
    biotech
    ai
  • Splendor
    Splendor
    Y Combinator LogoW2022
    Active • 1 employees • Cambridge, MA, USA
    Splendor's AI agent helps providers, EHRs, and billing companies automate benefits checks, prior auth, and more.
    health-insurance
    healthcare-it
  • Maven Bio
    Maven Bio
    Y Combinator LogoS2023
    Active • 10 employees • Boston, MA, USA
    At Maven Bio, we’re transforming BioPharma knowledge work by pairing domain-specific AI with curated industry data—letting consultants, investors, and corporate teams move from question to decision with less manual work. Our integrated BioPharma-specific platform features four flagship modules: • Maven Workflows: Monitor Maven's domain-specific AI through structured research tasks—step by step—and finalize results with confidence. • Maven Atlas: Access hundreds of pre-built indication landscapes, or generate custom ones on demand for in-depth insights. • Maven Compass: Build precise lists of companies, drugs, trials, or documents with advanced filters—move faster with AI-driven filter suggestions. • Maven Assistant: Get instant answers to your BioPharma questions, complete with direct links to primary sources. Stop burning hours on manual data hunts. Maven Bio’s continuously updated database and collaborative AI features empower you to focus on strategic decisions. We offer usage-based pricing and usage-restricted trials, plus custom solutions for unique data sources or specialized workflows. Trusted by life science consultants, BD teams, and investors worldwide, Maven Bio delivers faster, deeper insights. Book a call to learn how our purpose-built AI can transform your research and accelerate your success.
    generative-ai
    biotech
    healthcare
    enterprise
    healthcare-it
  • Yuma AI
    Yuma AI
    Y Combinator LogoW2023
    Active • 26 employees • Boston, MA, USA
    ## What is Yuma AI? Yuma is automating customer support by providing an AI Support Agent orchestration platform. Yuma provides autonomous AI agents dedicated to customer service and e-commerce. We integrate directly with help desk software (Zendesk, Kustomer, Gorgias, etc.) and focus on helping large Shopify brands deal with their high volume of support requests. Top merchants using Yuma can automate up to 80% of their support tickets fully autonomously. ## Why do Shopify merchants need Yuma? There are thousands of large Shopify merchants around the world generating $10M+ a year. Most of them have taken over some niches and are great at what they do: selling their products. But they all have one thing in common: they all hate customer support. It's a burden for them and a huge source of cost, as they receive hundreds of requests per day. Some of them have dozens of support agents on staff, usually offshore, and the overall quality is still often pretty poor while staff turnover remains high. Those merchants have been promised automation for years but have always been disappointed by the outcome. As customers, we have all had to live through a terrible support automation experience before, so this is no secret, and everyone knows that the current state of the technology is quite bad. ## Yuma is solving this in a few ways: Yuma isn't just another RAG chatbot. Our platform provides autonomous AI agents dedicated to support and ecommerce. These agents are powered by knowledge, follow processes, and are managed by our in-house AI orchestration technology. This ensures safety, control, and quality at every step. We believe that to truly automate customer support, we must develop a platform that mimics the actions of a human support agent. That's exactly what we've been doing. Currently, our top merchants are automating 60% of their support tickets through Yuma. Yuma can fetch information from external services and take actions in other apps as needed to resolve each ticket. We are laser-focused on building the best AI support agent platform and aim to achieve 80% true automation in the next few months. ## Fun Fact Yuma got started by accident. This is my third YC startup after Socialcam (W12) and Triplebyte (S15). I released Yuma as a prototype for fun in mid-December 2022 and was overwhelmed with demo requests. That's when I knew I was onto something and had to turn this into a real company, once again.
    artificial-intelligence
    customer-support
    ai
    conversational-ai
    ai-assistant
  • Vector
    Vector
    Y Combinator LogoW2023
    Active • 10 employees • Boston, MA, USA
    The world’s first and only intent platform based entirely at the contact level. Know exactly which contacts are in-market on and off your site.
    generative-ai
    saas
    b2b
    enterprise
  • Odigos Technologies Inc.
    Odigos Technologies Inc.
    Y Combinator LogoW2023
    Active • 16 employees • Boston, MA, USA
    Odigos leverages eBPF technology to create an open-source solution that can automatically generate distributed traces for any application without any engineering work. Developers are struggling with extracting and delivering high-quality monitoring data. Currently, building a pipeline is a manual process that takes months to implement, is an error-prone process that requires tons of code changes across multiple R&D teams, and demands collaboration.
  • Propexo
    Propexo
    Y Combinator LogoW2023
    Active • 6 employees • Boston, MA, USA
    Propexo lets engineers build, test, and launch CRE software integrations in days, not months. We modernize the developer experience for our customers, providing clear documentation and robust infrastructure to support the needs of property owners, property managers, & proptechs.
    developer-tools
    saas
    b2b
    proptech
    api
  • NuMind
    NuMind
    Y Combinator LogoS2022
    Active • 6 employees • Cambridge, MA, USA
    NuMind is a tool for data scientists, data analysts, but also software engineers to create custom NLP models. For example, a recruiting company uses NuMind to find which job offers best match a given resume. Etienne (CEO) was head of Machine Learning at Wolfram Research, and Samuel (CTO) co-founded Make.org (8M users). NuMind originated from our own frustration when developing NLP models. Leveraging large language models similar to GPT-3, NuMind allows to complete NLP projects at least 10x faster than before. We launched a private beta August 2 and had 9 paying customers one month later.
    aiops
    artificial-intelligence
    machine-learning
    nlp
  • Argument Computer Corporation
    Argument Computer Corporation
    Y Combinator LogoW2022
    Active • 8 employees • Boston, MA, USA
    Argument combines zero-knowledge cryptography, formal verification and distributed consensus technologies to build systems for unbreakable, scalable, private, decentralized software.
    crypto-web3
    security
    cryptography
  • Kodex
    Kodex
    Y Combinator LogoS2021
    Active • 30 employees • Boston, MA, USA
    Kodex makes it easy for companies to process, and respond to, subpoenas from governments around the world. Agencies, like the FBI, subpoena user data from customers like Coinbase, and thousands of other companies - without Kodex, companies largely rely on email, fax, and spreadsheets to manage them. Kodex is a SaaS tool that helps private sector companies manage relationships, workflows, and secure file transfer with government agencies who are seeking confidential information on a company's users. We streamline compliance operations, protect the privacy of their users, reduce error, and validate the legitimacy of government agents who are requesting information.
    govtech
    compliance
    legaltech
    regtech
  • Vendr
    Vendr
    Y Combinator LogoS2019
    Active • 50 employees • Boston, MA, USA
    Vendr built the AI negotiation agent that helps companies stop overpaying for software by using real contract data to benchmark prices and secure better deals automatically.
    saas
    finance
    procurement
  • Pyxai
    Pyxai
    Y Combinator LogoW2019
    Active • 5 employees • Boston, MA, USA
    Pyxai helps organizations evaluate, identify and source top talent by focusing on the best indicators of long-term job success, soft skills. Our proprietary, AI driven assessment tool helps organizations increase retention by at least 30% all while reducing the time to hire by more than 50%.
    saas
    b2b
  • Metaplane
    Metaplane
    Y Combinator LogoW2020
    Acquired • 32 employees • Boston, MA, USA
    Metaplane ensures everyone trusts the data that powers your business. Data teams at Bose, Ramp, and Klaviyo use our data observability platform to prevent and detect data issues — before the CEO pings them about weird revenue numbers. We do this with ML-based anomaly detection, end-to-end column-level lineage, and tools to help prevent incidents before they occur. You can monitor your entire data stack within 30 minutes. The company is backed by Khosla Ventures, Y Combinator, and the founders of Okta, HubSpot, and Vercel.
    developer-tools
    saas
    data-engineering
  • Gaiascope
    Gaiascope
    Y Combinator LogoS2019
    Acquired • 9 employees • Boston, MA, USA
    Software that simplifies electric grid forecasting and operations. Clients--hard assets like wind, solar and energy storage--get timely, unbiased information to improve revenues, reduce risk, and maximize the profitability of every megawatt. Gaiascope also manages a quant fund trading electricity; with this fund, the company builds additional credibility with clients and accelerates the continuous improvement of its software.
    climate
    energy
    climatetech
  • Ascen
    Ascen
    Y Combinator LogoW2019
    Acquired • 17 employees • Boston, MA, USA
    Ascen is a back office platform and employer of record for staffing firms.
    saas
    b2b
    compliance
    hr-tech
  • Hunter2
    Y Combinator LogoW2018
    Acquired0 • Boston, MA, USA
    Hunter2 teaches modern appsec to engineering teams through interactive labs. Developers get hands-on practice exploiting and patching real web apps written in their tech stack.
    developer-tools
    education
    cybersecurity
  • Moltin
    Moltin
    Y Combinator LogoW2015
    Acquired • 32 employees • Boston, MA, USA
    At Moltin, we believe that brand experiences should never be obscured by technology and that commerce development should be simple, lightweight and fun. Moltin is an API-first digital commerce solution that enables retailers to build distinctive shopping experiences and embed them into any consumer touchpoint. It combines an extremely flexible set of APIs, developer toolkits, pre-built applications and cloud infrastructure to make commerce development simple, lightweight and fast. Moltin APIs are the simplest, most powerful in the industry. Retailers can test new channels quickly, scale into new markets, and keep pace with ever-evolving consumer trends. With Moltin, commerce flows seamlessly across any channel, device and experience. Moltin has a rapidly growing community of more than 17,000 developers around the world, pushing the boundaries of traditional commerce.
    payments
    e-commerce
    api
  • Kiko
    Kiko
    Y Combinator LogoS2005
    Acquired0 • Cambridge, MA, USA
    Kiko is a web calendar for anyone who wants to keep and share a calendar online. Kiko excels at three main things: * Universal access: Kiko integrates with your mobile phone and AIM and lets you access your calendar from any computer. * Share your calendar: Invite anyone to events (not just other Kiko users!) Let others view your calendar with just a click. * As easy as paper - or maybe easier: Write "Pay gas bill every month" onto your calendar and watch Kiko do the Right Thing!
    calendar
  • Cloudant
    Y Combinator LogoS2008
    Acquired • 51 employees • Boston, MA, USA
    Cloudant's distributed database-as-a-service (DBaaS) allows developers of fast-growing web and mobile apps to focus on building and improving their products, instead of worrying about scaling and managing their databases on their own. We manage and distribute your data globally so you can grow more users, build more app features, and sleep more knowing we're keeping the servers up and humming. Cloudant was founded in Cambridge, Massachusetts in 2008 by three MIT physicists who at the time were moving multi-petabyte data sets around from the Large Hadron Collider. Frustrated by the available tools for managing and analyzing Big Data in their research, the founders built a distributed, fault-tolerant, globally scalable data layer on top of Apache CouchDB. The service has grown since then. The team now manages and serves mobile and web app data on behalf of thousands of developers and hundreds of customers to their users around the world. In 2014, the company was acquired by a global enterprise software & hardware vendor.
  • Embedly
    Y Combinator LogoW2010
    Acquired • 2 employees • Boston, MA, USA
    Embedly provides a platform and suite of tools to make embedding and previewing links simple. Embedly helps publishers and consumers manage embed codes from more than 100 Websites and APIs, including YouTube, Flickr, Ustream, Picassa, Hulu, Twitpic, Quantcast, and CrunchBase. It automatically convert links from these sources into embedded media on the fly.