Healthcare Startups funded by Y Combinator (YC) 2024

Ginkgo Bioworks is the organism company. We design custom organisms for customers across multiple markets. We build our foundries to scale the process of organism engineering using software and hardware automation. Organism engineers at Ginkgo learn from nature to develop new organisms that replace technology with biology.

Notable Labs is building a personalized drug discovery platform to identify treatment options for relapsed and refractory cancer patients — starting with blood cancer — to address the long tail of cancer treatment. We look at a person’s actual cancer cells, test combinations of FDA approved drugs, and see which combinations kill the cancer cells and leave the healthy cells alive. We focus on combinations because cancer is often difficult to target with just one drug and starting with a single drug can lead to resistant clones or relapse. We're building a highly automated lab in Foster City running on our custom software and are currently testing relapsed/refractory cancer patients as well as samples from a variety of pharma/biotech partnerships. https://www.notablelabs.com/careers

We make oral drugs to treat and prevent viral infections - like COVID-19.

Diassess Inc. is revolutionizing the way infectious diseases are prevented, diagnosed, and monitored by developing the tools necessary to empower people to become knowledgeable about their health. We produce inexpensive, disposable health diagnostic hardware that transforms any smartphone into a portable, real-time health-monitoring device for rapid, accessible, multiplexed analysis of bodily fluids anywhere in the world.

Clipboard Health exists to lift as many people up the socioeconomic ladder as possible. We dramatically improve lives by letting healthcare professionals turn extra time and ambition into career growth and financial opportunity. We achieve this with our app-based marketplace that connects healthcare facilities and healthcare professionals, allowing healthcare professionals to book on-demand shifts and healthcare facilities to access on-demand talent. Our mission is to enable healthcare professionals to work when and where they want and to enable healthcare facilities to meet their talent needs. Clipboard Health is a fast-growing Series C startup with classic two-sided network effects. We have product-market fit, generate substantial revenue, and we are helping nurses fix healthcare one shift at a time. Clipboard Health is a diverse and inclusive company with a global, remote-first team of hundreds of people. We’ve been featured on YC’s Top Companies and grown our revenue 25x in the last 18 months. We need your help to keep growing so we can serve more healthcare professionals, healthcare facilities, and patients.

Nurx is a telemedicine startup focused on increasing access to healthcare, starting with birth control and PrEP services.

We're a women’s health company making personalized reproductive health information more accessible, earlier in life. We make the same laboratory tests that were previously confined to fertility clinics more accessible for women at home. By arming women with powerful information about their reproductive health, Modern Fertility is closing the fertility information gap and enabling women to own the decisions impacting their bodies and futures. We've raised $22 million from Forerunner Ventures, Maveron, Union Square Ventures, First Round Capital, #Angels and Y Combinator.

DrChrono develops the essential platform and services for modern medical practices to make care more informed, more interactive, and more personalized. The open platform powers telehealth, electronic health record (EHR), practice management, medical billing, and revenue cycle solutions for physicians and patients, and is fully extensible via a robust API and marketplace of applications and services. The platform is used by thousands of physicians and millions of patients, and is facilitating millions of patient appointments and is processing billions of dollars in medical billing. For more information about DrChrono, visit www.drchrono.com

Planbase has everything health clinics need to manage their team in one place: capacity planning, employee scheduling, credentialing and payroll.

Attunement an automation workflow platform for psychiatric assessments.

Helium Health provides a suite of digital health tools for healthcare providers, payers and patients across Africa — most prominent of which is our maiden electronic medical records (EMR) & hospital management information system (HMIS) for emerging markets, HeliumOS. We offer business loans to healthcare providers through our HeliumCredit product. We also work with donors and governments in executing public health strategies. Finally, we have built the largest healthcare data repository on Africans with over 1 million health records.

Altay develops small molecule drugs to treat chronic liver diseases like liver fibrosis and liver cancer. Our co-founder Dr. Osman Ozes, led the first drug development program for Esbriet (Pirfenidone), resulting in the first FDA approved therapy for lung fibrosis. Esbriet is now a $1 billion/year drug and has already made over $6 billion in revenue. With a team that has over 70+ years of small molecule drug development experience, we intend to do the same with chronic liver diseases, which affects over 20 million Americans and represents a market size of over $30 billion. We know we are well positioned for success because we have shown excellent pre-clinical mouse data in several liver fibrosis models using our novel small molecule. We demonstrate a reduction in fibrosis with our drug, but more significantly, we show a reversal in fibrotic tissue back to normal tissue. With our current developmental strategy, we hope to have a clinic-ready compound by the end of 2021 and be in phase I clinical trials by mid of 2022.

Rev Genomics is a plant biotechnology company that provides breeders, growers, and retailers with novel cultivars to differentiate themselves in high value markets.

38 million people suffer from heart rhythm disorders and are recommended to start medications that can save their lives, but require rigorous ECG monitoring to start and remain on these pills. SafeBeat Rx moves beyond diagnostics to guide these therapeutics, powered by our ML ECG software that integrates with existing FDA-cleared wearables to allow seamless physician approval of drug dosing, all from a mobile phone. We are a team of physicians, engineers, data scientists, and machine learning experts dedicated to using engineering to improve heart health.

Segmed provides at-scale access to novel clinical data globally, offering millions of diagnostic-grade medical images to accelerate innovation and mature the evidence needs of life sciences and technology industry. ‍ Our solutions allow you to access a Real World Data (RWD) network to facilitate rapid discovery and investigational capability of imaging data, development of early disease detection & prediction models, improved patient recruitment and reduced operating burden to access therapeutic data ecosystem.

SynsoryBio is creating next generation, protein therapeutics that sense where they are in the body and only activate at diseased tissue. This technology platform has the potential to expand the therapeutic window of highly potent drugs and apply to many diseases such as cancer and autoimmune disorders.

We make it easy for anyone in India to access healthcare over Zoom, Meet, or WhatsApp. We provide care in 11 local languages. For every appointment, we provide a concierge who manages all logistics for the patient & handles the back-office work for doctors. With this, we have cracked the code to make telehealth work in India.

Pharos automates hospital quality reporting, saving millions in labour costs and helping to prevent avoidable patient harm. Today, clinicians spend thousands of hours manually pulling complex facts out of medical records for mandatory reporting and quality improvement. Our AI pulls those facts out of unstructured medical records automatically. We automate reporting and show staff where avoidable patient harm is happening.

AlemHealth connects hospitals and diagnostic centres in emerging markets to a global network of diagnostic imaging services. Our suite of plug-and-play radiology solutions makes it easy for any facility anywhere to access and provide world-class diagnostic care to its patients. We designed our hardware and software from the ground up specifically for emerging markets, where access to internet, electricity, and clinicians can be difficult. Learn more about our solutions at www.alemhealth.com.

Medplum makes it easy to build healthcare webapps that are compliant and interoperability ready. Our open source toolkit allows healthcare providers write apps that are HIPAA compliant, SOC2 certified and FHIR native - streamlining payor connections, health system integrations and more.

Pair Team cares for the highest-need Medicaid recipients through a community-led, virtual care model. We take responsibility for the whole person by addressing not just clinical needs, but also health-related social needs such as housing instability and food access. We partner with local community-based organizations like shelters and safety net providers to coordinate care alongside our multidisciplinary care team to improve the wellbeing of underserved individuals and communities.

Reliance Health uses technology to make quality healthcare delightful, affordable and accessible in emerging markets. Through an integrated approach that includes affordable health insurance, telemedicine and a combination of partner and proprietary healthcare facilities, Reliance Health offers innovative healthcare solutions that meet the needs of emerging markets including Nigeria, Egypt and growing

Wyndly (https://www.wyndly.com) fixes allergies by training patients' bodies to ignore their allergy triggers. Frustrated allergy suffers come to us when they no longer want to deal with pills and sprays. We diagnose the patient’s unique allergy profile and create a personalized treatment plan to give the patient lifelong allergy relief. Specifically, Wyndly is increasing access to sublingual immunotherapy (SLIT) for allergy care. For our patients, we're combining the convenience of telehealth and direct-to-consumer care with an exceptional patient experience that never loses the context of care. Wyndly represents an opportunity to change allergy care forever. With 60 million Americans suffering from allergies today, and with this number doubling over the coming years, there's simply an incredible need for the convenient care Wyndly provides. You can read more about us in [Techcrunch](https://techcrunch.com/2021/02/12/wyndly-aims-to-bring-allergy-drops-to-the-masses/). The Wyndly Model At Wyndly, we believe that better connections lead to better care, and we’re committed to making both happen at every step of the patient journey. Our allergy practice allows our patients to work with expert providers to develop personalized treatment plans for long-term allergy relief using clinically proven therapies. From a patient’s initial consultation to their final treatment delivery, we want the Wyndly experience to be a breath of fresh air for allergy sufferers – truly effective allergy relief, simply and efficiently delivered. Once we've conquered allergies, we're transforming the care model for every chronic condition. While transactional care for purchasing pills has flourished in telehealth, no one has gone after chronic care. Patients with chronic conditions are shuffled between providers, insurance, and more -- and they never feel heard. These patients deserve better, and we're going to give it to them. Wyndly is starting with allergies, but we'll expand into asthma, sleep apnea, and other conditions in the near future. Our values **Compassion**: We approach all our patients and partners with an open mind and a genuine desire to be of service. **Focus**: We do a few things very well, and are always clear about our boundaries and direction of travel. **Courage**: We embrace ambiguity and discomfort because we know that’s how we grow. **Progress**: We make something better every single day. *It boils down to empathy and forward momentum in everything we do.* The team Wyndly is proudly backed by Y Combinator and a leading group of angel investors and VCs. The founders are Dr. Manan Shah (Chief Medical Officer), an ear-nose-and-throat surgeon who’s a leading practitioner of telehealth in his specialty, and his cousin Aakash Shah (CEO), who led growth engineering at SparkGift (acquired by Stockpile in 2016) and Parse.ly (acquired by Automattic in 2021).

Illuminant is helping surgeons perform safer and more efficient surgeries by projecting visual guidance directly on the patient’s skin. Using computer vision and low cost hardware, we can display patient-specific anatomical structures from preoperative medical images (e.g. CT scans), pre-operative annotations from planning, and real-time feedback, like needle depth and tool trajectory, as a surgeon operates. Our vision is to expand surgical navigation to underserved health systems and surgical specialties.

Shimmer provides ADHD coaching to people with ADHD or executive function challenges. Shimmer was born from a group of ADHD coaches, psychiatrists, doctors, and engineers to create a personalized, action-oriented playground for you and your coach to explore. We're not another list, calendar, or app: we're real human interactions paired with expert strategies, so that you can make real changes in your life. Come check us out! Our ADHD coaches partner with you to co-design a plan to achieve your goals. You'll experiment with strategies on a weekly basis to implement a routine fit specifically for you. Our program has been designed off science-backed methods in partnership with NYU, UC Berkeley, and UCSF. Get your free ADHD Mastery Score > https://www.shimmer.care/assessment

Adoption of Telehealth 1.0 has dropped to <5% because it's inefficient and unintelligent. Ankr uses generative AI to recreate functions of clinic staff including front desk, medical assistants and scribe. This allows Doctors to "spin-up" virtual clinics on-demand, anytime, anywhere. An average clinic using Ankr generates $1M in new revenue/year. We integrate with all top EHRs and work with all types of clinics in mid- to large-sized healthcare organizations.

Probably Genetic is changing the lives of patients living with severe, complex diseases. Our data platform is used by drug developers and patient advocacy groups to develop and launch treatments for these patients. Our technology discovers undiagnosed patients online, analyzes their disease state using machine learning and at-home testing, and enables compliant communication with patients. In doing so, we help patients access diagnoses, clinical trials, and treatments as early as possible.

Ply helps behavioral health providers (e.g. therapists, social workers, psychiatrists) see more patients by getting them in network with insurance companies like Aetna or Medicaid. Ply submits enrollments 2x faster using automation and AI enabled data validation.

Leveraging AI to provide veterinarians with more accurate and affordable diagnostics.

Andson Biotech helps pharmaceutical companies measure difficult to detect chemicals that they need to measure while developing and manufacturing drugs like cell-therapies or biologics. Drug companies want to use our technologies to get fast and accurate chemical measurements they do thousands of times per day for drug development and quality control.

The main document in a clinical trial is the study protocol. At large companies, floors of people use the protocol to create the study data collection forms, clinical database design, error checks, analysis code, and data transformation mappings. We use AI to automate the process of creating everything from the protocol, saving not only spend on headcount but also months of time which can translate to up to $27M in direct costs + lost revenue saved for a single phase 3 trial.

Out-of-pocket healthcare costs are skyrocketing and every day, people all across America are forced to make difficult decisions about their health. Lively is the benefits solutions provider that gets it right. We designed our solutions to take the guesswork out of managing benefits. And our innovative features are built to simplify benefits administration and evolve with your business. Managing wellness and wealth takes more than a series of transactions. By combining robust features with unparalleled service, we make benefits administration effortless, even when time and energy are limited. Experience benefits administration as it should be with Lively. Go to www.livelyme.com to learn about how HSAs other modern employee benefits can help you and your team.

Proteins are the most advanced nanotechnology we know of. At Adaptyv Bio we’re building a fully automated protein foundry to allow you to synthesize and test any protein you design.

We're building curative gene therapies for kidney diseases. Our initial focus is on polycystic kidney disease (PKD), which affects 600,000 Americans and has no effective treatment or cure.

Founded in 2010, Lygos is providing biotechnology solutions for today’s renewable chemical challenges. They engineer microbes to convert sugars into high-value, industrial chemicals, targeting compounds where biological production is cost-advantaged over petrochemical production.

Perlara 1.0 (Feb 2014 - Feb 2019) launched early R&D joint ventures called PerlQuests with highly motivated rare disease families, companies or impact investors. We screened gene-edited patient avatars for repurposable drugs in order to build a predictive R&D engine called ArkBase. We planned to monetize programs based on ArkBase predictions by selectively spinning out asset-centric clinical development NewCos. Perlara 1.5 (March 2019 - April 2020) was the transition to a one-person virtual clinical development company and when the epalrestat and aripiprazole repurposing trials were launched at Mayo Clinic for the treatment of PMM2-CDG and NGLY1-CDDG, respectively. Perlara 2.0 (May 2020 --> The first decentralized and distributed biotech

Sample Healthcare is the fastest way for healthcare organizations to responsibly deploy AI in their operations. We help teams build custom copilots for their administrative tasks, like getting paid by health insurance, and then use the data from those copilots to fine tune task specific models.

Granza Bio is developing cancer therapeutics modelled from our body’s own immune system. Our therapeutics termed “attack particles” are engineered to specifically target only cancer cells, preventing any unwanted toxicity and adverse side effects. Our attack particles have shown cancer-killing efficacy in brain (glioblastoma), ovarian, lung, and skin cancers. Our platform can also be deployed to target a great range of diseases including autoimmune diseases and infections. Interested to know more? Get in touch founders@granzabio.com!

Spot is building the infrastructure to support the future of at-home diagnostics. Our fully white-labeled platform helps brands offer lab-analyzed diagnostic tests using at-home collection kits. Companies simply order tests via our API, and we handle the rest—the collection kits, the logistics, physician authorization, and the lab integrations.

Orchid is an AI-powered Electronic Health Record (EHR) for independent mental health professionals that saves them time, money, and frustration by integrating core administrative workflows, streamlining clinical processes, and automating manual flows.

Helping pregnant parents save the most personal source of stem cells - from their umbilical cord and placenta - to unlock future disease treatments. Offering cord blood banking, cord tissue banking, and placenta stem cell banking.

Penciled (W24) helps physical therapists fill 10X more canceled appointments. The core of our product is an AI agent named Nicole. Nicole helps patients join the waitlist, maintains live availabilities, and texts and calls waitlist patients to fill canceled appointments. When fully deployed, Nicole fills 79% of cancellations detected and takes an average of 3 minutes to fill an appointment. Therapists using Nicole see a 194% increase in cancellations filled.

BrainKey is an AI-driven digital healthcare company with a mission to create a world free from dementia. The company specializes in developing advanced clinical technologies that empower longevity physicians to detect and prevent cognitive decline and other brain longevity challenges. By analyzing brain MRI and biomedical data, BrainKey provides highly accurate and personalized brain health insights, supporting physicians in delivering tailored care for brain longevity. BrainKey's AI-powered platform streamlines diagnostics and reporting, improving both clinical outcomes and financial efficiency across the continuum of brain health care. Short Clip about BrainKey from the BBC: https://www.youtube.com/watch?v=ioSgvROTP0E

Helpcare builds AI Agents to take on coordination burden from staff and reduces time of care by autonomously identifying and outreaching patients (through phone, text, email, & mail) to schedule visits, book screenings, complete pre-post, and onboard. These agents require no integration, can navigate all tools, speak 29 languages, come with 50+ outreach scripts and have a remarkable 80% conversation-to-booking closing rate.

Blueberry Medical provides concierge pediatric care with at-home medical diagnostics and an always-available team of Pediatricians. Blueberry handles twice as may illnesses as any other telemedicine provider and has proven to reduce ER costs by 50%.

Alzheimer’s is tough. And while there is no cure, getting help should be 100x easier than it is today. We’ve raised over $6 million to solve that problem. When someone is going through the disease, there are many different things they need help with (i.e. memory issues, depression, fall risk, safety in the home, etc). The primary person responsible for that care is one of the patient’s loved ones – usually a child or a spouse. That’s a really difficult thing for the loved one to do. It’s stressful, time consuming, and difficult. If we can make their lives easier, we can not only improve their experience but also create better patient outcomes. We’re building the world’s first one-stop-shop, d2c care platform for Alzheimer’s, starting by optimizing the care monitoring, management, and intervention processes.

We are a drug discovery company developing a new generation of therapeutics that embrace the complexity of disease. Currently available approaches for creating drugs work on the principle of finding one drug-one protein 'magic bullets'. However, diseases such as cancer and autoimmunity are often the result of several dysregulated proteins across many distinct biological pathways. We are building a computational-experimental platform to design therapeutics that can target several disease-causing proteins at once. By designing multi-specific drugs, we are able to create therapeutics that are more efficacious and safer than existing medicines.

Terapify offers high-quality on-demand mental healthcare for individuals and businesses. Currently, people in more than 45 countries take therapy with us on a recurring basis every month.

Asha Health enables medical practices to launch their own AI clinic, designed to fill crucial care gaps that their brick & mortar clinics are too overburdened to address — all while generating additional revenue on autopilot.

Isabl has developed software that can analyze the entire genome of cancer patients. Today, when people get cancer, they get a genetic test of their tumor that analyzes only a few possible mutations. With Isabl, you run the tumor through an Illumina sequencer and get the whole genome, then our software is able to analyze all the mutations. Our breakthrough technology provides unprecedented clarity into tumor biology to aid treatment planning. This opens up opportunities for precision diagnostics, disease surveillance and biomarker discovery.

We are on a mission to help people understand what influence how they feel and what they can do to feel better. Stoic has more than 3 000 000 downloads, 50 000 reviews with a 4.8/5 average and you can find it here http://apple.co/-stoic and here http://apple.co/stoic

DNA has emerged as a compelling data storage medium due to its density, longevity, and eternal relevance compared to current memory technologies. However, the high price of synthesizing DNA remains a major bottleneck for adoption of this promising storage solution. We are pioneering new approaches to synthesizing DNA for data storage with enzymes and custom digital codecs. We are building an interdisciplinary team to build the world's most scalable information infrastructure in DNA. We seek technical experts in enzyme engineering, chemistry, hardware engineering, and information theory. We also seek business development to identify emerging markets for early use cases of our technology.

Dr. Treat is a tech enabled modern veterinary care company offering virtual and in-clinic services to pet parents. We are building the largest pet health company powered by technology and driven by data to offer highly personalized & preventative care for every pet.

SmartSpot is a post Series-A stealth startup backed by Founders Fund and Khosla Ventures that uses computer vision to deliver an unparalleled fitness training experience to your home. Our unique hardware solution gives amazing trainers the ability to see their class participants in real time and deliver detailed advice that was previously only possible in person.

Brave Care is a group of kid-only primary & urgent care clinics that create a comfortable environment for little ones and reduce the stress and cost of emergency medicine for parents. We are 1/10th the cost of an ER trip and most often a visit can be completed in 1/4th the time. Common treatments: Pinkeye / Allergies / Tummy Bugs / Stitches / Broken Bones / Head Bumps / Sore Throats / Coughs / Fevers. Our digital services leverage our in-clinic medical professionals to reach across the country.

AlgoSurg makes AI software solutions, for various next-generation surgical applications ranging from Robotics-surgeries, AR-based-navigation/training, cloud-based 3D surgery planning and automatic patient-specific instrument/implant design.

Decoda Health centralizes communications between healthcare clinics and patients along with a comprehensive payments platform. Our platform makes it easy for patients to communicate with their healthcare providers and pay for services all in one place.

The world’s No. 1 lab management platform. We help scientists easily organize orders, manage inventory, and save money.

We believe that no emergency should have to wait. To make this a reality we build AI that instantly reads medical scans and enables critical care teams to make diagnoses better than radiologists. This saves lives by getting emergencies to treatment immediately and by discharging non-emergent patients quickly so the next emergency doesn’t have to wait either.

Papa is a one-stop-shop for flexible family care, providing companionship and a helping hand wherever it’s needed. With wide-ranging industry, technology, and transformation experience, we share a vision for a world where no one has to go it alone. And a deep well of gratitude for the Papa People who move this vision forward. Founded in 2017 and headquartered in Miami, Papa is backed by Canaan, Tiger Global Management, Comcast Ventures, SoftBank Vision Fund 2, TCG, Initialized Capital, and Seven Seven Six, among other revered institutional and individual investors. Papa is an equal opportunity employer. We proudly support the ParityPledge® for gender and/or racial parity at the highest levels of business.

We help large provider groups and hospitals take their most mundane repetitive tasks and turn them into automated workflows. Freeing up healthcare workers to focus on the important stuff, like patients

Float brings a nurse to your home when you’re sick. If you have a chronic illness, instead of making you come to an overcrowded hospital full of sick people, we bring the best of the hospital to you.

It takes 5 years for pharma to develop long lasting drug injections for chronic diseases like cancer and diabetes. Persist uses AI-driven automation to reduce formulation development time down to 2 years, a ~50% reduction.

We enable people to live their best lives. As we succeed, there is more convenience, healthier communities and thriving businesses. We get medications to those who need them and improve information, access and management of their care and enable businesses to move online and gain access to consumers who need their services

Moons manufactures and sells orthodontic clear aligners in LATAM. Our focus is on providing excellent patient service whilst keeping prices accessible - we can do this because we make the aligners ourselves in our dental laboratory and sell the aligners exclusively in our own clinics

At Pirouette, we have developed a low-profile, disk-shaped, rugged injection device with a patient-centric focus on affordability, portability, and usability. The patented device, based on extensive patient input, is designed to make administering an injection as easy as pushing a button. This allows individuals with limited or no training to easily and intuitively perform an injection on themselves or others.

At iMicrobes, we believe there are opportunities for biology to solve our biggest problems. Our mission is to work with the world’s largest companies to use new raw materials and recycle waste for chemical production, polymers, agriculture, and space exploration.

As healthcare costs have increased, the patient's home has become incredibly important as a site of care. Yet, patients recovering at home are highly underserved. Patients can only get better at home if they receive the high-quality care that they need reliably. The existing in-home care process involves patchwork of different vendors, all connected through faxes by nurses. We're building modern, robust software that solves this challenge and brings this market online.

We are building a platform of bacterial molecules to awaken our body’s innate ability to control inflammation and heal. Our first indication is Crohn’s Disease, which affects over 500,000 Americans at an annual cost of $10B. After Crohn's disease, we are going for type 1 Diabetes and Multiple Sclerosis.

AesculaTech believes in building better lives through smart chemistry. We design custom smart materials for a range of biomedical, commercial, and industrial applications. Our platform technology, AesculaGel offers adaptive response to a wide range of stimuli and can be tailor-made for biocompatibility, material strength, and a range of other attributes. Founded by one of MIT's 35 under 35 Innovators, AesculaTech is the shared vision of scientists, engineers, and medical experts. Our cornerstone product, Humidifeye, is an ophthalmic platform to treat dry eye disease. Dry eye affects more than 25 million Americans and the global treatment market is projected higher than $6 Billion within the next decade. Our thermally responsive, form-fitting materials are suitable for sustained yet reversible occlusion across a range of treatment times. In contrast to existing technologies, our product will not extrude, or cause discomfort as it adapts to patients. Though Humidifeye is not yet FDA approved, expect to hear about it soon! In coordination with partners across several sectors, we have a variety of groundbreaking technologies in the works that live up to our vision. This work has already been recognized. AesculaTech was named a Rosenman Innovator, received a National Science Foundation I-Corps grant, was a finalist in the 2019 Octane High Tech Awards, and is a graduate of both the Y Combinator and TMCx accelerator programs. In short, Y-Combinator was only the beginning.

Mindset Health is on a mission to empower a billion people to manage their health by unlocking the power of their mind. We're building a digitally native ‘pharma’ company that allows us to quickly turn hypnotherapy research into highly effective, consumer-friendly mobile apps. Mindset Health makes hypnotherapy accessible for people suffering from irritable bowel syndrome, menopause, chronic pain, depression, and more - who no longer have to pay thousands of dollars and wait months for in-person support. By digitizing a previously stigmatized therapeutic tool, we make it accessible and help it achieve the same efficient scalability, consistency, instant availability, and ease-of-use of drugs but with the feedback loop of an app.

CareRev is a technology platform empowering healthcare professionals to take control of their careers. CareRev provides a direct line between healthcare facilities and local clinical talent, cutting out the middleman and enabling professionals to work where and when they want. Together, we’re building the local, resilient, flexible healthcare workforce of the future. For more information, visit carerev.com or follow us on LinkedIn.

Finding new cures requires seeing what and where the abnormal molecules are in a diseased tissue, but current tools see less than 1% of those molecules. Biocartesian combines microscopy and new chemistries to see 50X more, offering unprecedented insights into disease biology and new therapies.

BloomAPI simplifies how medical records are transferred. Today the majority of records are still moved by fax and couriers. Patients, Doctors, and Insurance companies all benefit when medical records are available when they are needed for the care of patients. We make this possible.

We make software to automate call shift scheduling for hospital residents/faculty and generally help hospital administrators keep track of their departments. Hospitals have long lists of requirements and rules they must follow, leading administrators to spend hundreds of hours a month ensuring their departments adhere to guidelines.

Codes automates patient record collection for providers. Today, documents are scattered across EHRs, other doctors, and faxes; we use AI to compile & analyze docs before the first appointment.

Building a standard-of-care medical device to freeze abnormal cells before they become cervical cancer, in any clinic, anywhere in the world, at 1/10 the cost. -- Ananya Health is building a portable cryoablation unit designed for every primary care clinic in the world. Our beachhead application is cervical cancer prevention -- even though cervical cancer is easy to screen for, 80% of clinics worldwide lack the infrastructure and specialized staff to treat at the earliest stages. Our platform technology allows nurses and lower level health workers to treat at the point of care for 1/10 the cost of traditional ablation, and is the only cryo device that will help us achieve the WHO target to eliminate cervical cancer in our lifetime.

GEn1E Lifesciences is a Clinical-stage, multi-target company with a unique AI platform. We develop novel, next-generation, immunomodulatory therapies for rare & inflammatory diseases with no effective treatments. Our team is supercharging the drug development cycle by applying AI to multiple-mechanism-of-action protein targets and their natural platform capabilities—creating novel therapeutics at an unprecedented pace. Our AI platform has enabled us to develop a purpose-built therapy for ARDS to reduce its $20 billion cost on society (just in the USA). GEn1E has built a rich pipeline of 21+ novel and selective immunomodulators and has plans to accelerate 2 additional devastating diseases (beyond their lead indication) to IND in the next 12 months. Our AI platform enables tremendous pace and capital efficiency as demonstrated by our progress in ~2 years with seed capital—a stark contrast to the typical spend of $100M+ and 7+ years exhibited in the pharmaceuticals / biotech industry. With ~90% of rare diseases having no therapeutic treatment at all, GEn1E is taking a giant swing that will hopefully bring life-saving therapies to the lives of patients in need. The team at GEn1E has decades of experience in drug development and machine learning. We graduated from YCombinator and Stanford-StartX in late 2019. We are based in Palo Alto, CA.

Asher Bio is a biotechnology company developing precisely targeted immunotherapies for cancer and other diseases. Our cis-targeting platform aims to enable selective activation of specific immune cell types, addressing the inherent limitations of otherwise pleiotropic immunotherapies that act on multiple cell types. Our approach has the potential to precisely direct different immune mediators against a range of target immune cell-types and create best-in-class immunotherapies in cancer, autoimmune and infectious diseases. Asher Bio is backed by Third Rock Ventures and is located in South San Francisco.

At Serif Health, we are taking the complexity out of the cost of healthcare. Our mission is to make healthcare pricing and contracting more transparent, easier to understand, fairer, and ultimately more affordable for all. New price transparency regulations have made a wealth of healthcare pricing and reimbursement data publicly available for the first time, but it is still extremely hard to ingest, organize, and actually use this data to understand the cost of care. That’s where we come in. Serif Health is building healthcare price intelligence data products and APIs to power the future of more transparent healthcare. We are an early-stage, venture-backed startup with a small, collaborative team of healthcare experts, engineers, and designers. We are excited to add new team members motivated by our mission, passionate about making a difference in healthcare, and looking forward to learning and growing from the challenges we will face along the way!

Almond is like One Medical but for women’s health: we make it easy to get great ObGyn care fast, both at our in-person offices and over telehealth. The problem with traditional ObGyn practices is that physician time is misused, so patients get slow care. We're rebuilding back-office tech that saves physicians time, and we're hiring a wider range of care providers roles, which let us deliver better outcomes to patients and reduce the amount of time it takes to get their issue resolved.

Matrubials is an anti-infectives company, focused on human milk peptides as therapeutics to address antimicrobial resistance and modern diseases. Currently the global rise in severe bacterial infections and the drying pipeline of effective treatments are burdensome for healthcare and economics. Sculpted by evolution, milk, first food for the newborn, provides an exemplary solution to address the nutritive and protective challenges an infant is faced with. The anti-pathogenic molecules from milk can be developed into therapeutics geared towards all-age diseases. Our first indication is bacterial vaginosis, a bacterial dysbiosis related inflammation that results in recurrent infections, disruption of homeostasis and long-term clinical complications in women of reproductive age, including but not limited to preterm births, fertility issues and increased rates of STDs. Our next inflection point is the evaluation of rapidly acting and selective candidate peptides in pre-clinical host impact and early safety studies, which can aid clinical and portfolio development towards topical applications.

In the global fight against breast cancer, Digistain stands at the forefront, offering a beacon of hope to millions. Our journey began at Imperial College London, where ground-breaking research gave birth to a technology poised to revolutionize breast cancer diagnostics. The Challenge: Every year, breast cancer affects 2.3 million individuals globally. Post-surgery, 60% of patients are advised to undergo genomic testing, an expensive and time-consuming process monopolized by a single lab in the U.S., costing around $4,000 and taking nearly two months. Consequently, only 5% undergo this vital testing. The rest, unable to access this crucial diagnostic step, often resort to chemotherapy—a treatment that, in one in four cases, is more harmful than the cancer itself. Our Solution: Digistain addresses this critical gap. Our technology transforms the current diagnostic process by enabling hospitals to analyze patient samples in-house using existing equipment, supplemented with our innovative technology. This approach offers near-instantaneous decision-making data, a stark contrast to the existing month-long waits. Central to our technology is a proprietary algorithm that identifies a unique spectral fingerprint of the tumour in the infrared spectrum, providing a personalized risk score. This score guides oncologists in selecting the most effective, individualized treatment plans, potentially reducing unnecessary chemotherapy and its harmful side effects. Impact and Potential: Our solution not only challenges the status quo in technology but also in accessibility. In a landmark government-commissioned study, Digistain demonstrated clinical evidence on par with the market leader, but at a fraction of the cost and time. Already making waves in clinical practice globally, with insurance reimbursement at leading cancer centers, our technology represents a paradigm shift in cancer care. Recognized by the Institute of Physics, the Royal Society, and Imperial College for our innovative contributions, and supported by entities like the NHS, Y Combinator, and the European Investment Bank, Digistain is more than a company—it’s a movement towards equitable, effective cancer treatment. With the potential to democratize access to life-saving diagnostics, Digistain is not just envisioning a better future for cancer patients; we are actively creating it.

Digital Clinics are facing an existential problem - fix margins, or die. We’ve built a clinic, and seen the tech they need to fix their margins. Now we’re bringing this tech back to other clinics. For our first customer, we’re projected to generate $2.5M in revenue.

Heart failure impacts millions worldwide and is associated with poor quality of life and high mortality rates. Because the heart cannot pump efficiently, fluids buildup around the body. Fluid overload is the main driver behind patient symptoms (shortness of breath, fatigue, chest pain, etc.) and hospitalizations. Our minimally invasive device leverages the body's innate fluid management system to offload trapped fluid and prevent subsequent rounds of buildup. The one-time procedure has sustained effect -- keeping patients healthier, happier, and out of the hospital.

Revolve is building the world’s only surgical robot designed for every operating room. Its simple yet powerful design makes it the only robot that can service the 1M+ abdominal surgeries performed outside of hospitals in the US every year. Revolve’s surgical robotics platform has been developed in collaboration with over 50 surgeons, resulting in a system that is just 1% of the size and cost of competitor devices.

Endpoint Health is on a mission to address urgent needs in immune-driven critical and chronic illnesses by delivering therapies that are personalized to each patient’s biology. We built Endpoint Health from the ground up to develop and commercialize therapeutics and therapy-guiding tests, to ensure that every patient receives personalized treatment that will dramatically improve their outcomes. Our vision is a world in which all patients have effective, personalized treatment, because therapies are targeted to the right patient at the right time.

We are developing cancer therapeutics using small molecules that inhibit immune suppression. Our drugs engage the immune system to aggressively fight tumors. In addition, our drugs have a unique delivery mechanism known as hypoxia-activated prodrugs (HAPs). HAPs are drugs designed to become active in a hypoxic (low oxygen) environment, which is a hallmark of the majority of solid tumors. By delivering active drugs only to the tumor site, we hope to overcome systemic toxicity in cancer therapeutics. Our therapeutic portfolio addresses a range of solid tumors, starting with mesothelioma.

MICSI is introducing AI software that doubles resolution and halves scan time. This breakthrough enables imaging centers to significantly enhance their capacity and patient throughput, potentially saving countless lives and generating an additional $2 million of revenue per MRI scanner. Our initial offering serves as a stepping stone toward the company’s larger vision of transforming the MRI into a truly quantitative instrument that is capable of providing highly reproducible data for more accurate diagnoses and patient management.

Archform is teeth aligner software startup that lets orthodontists create, design and 3D print aligners within their own offices. The idea is to provide orthodontists with a way to better compete against some direct-to-consumer teeth aligner startups and cut down on the cost of Invisalign.