Healthcare IT Startups funded by Y Combinator (YC) in the San Francisco Bay Area 2025

MentalHappy is a secure and compliant platform that leverages AI and data-driven analytics to enhance the group-based therapy experience and boost client/patient engagement. Our platform streamlines administrative tasks for providers, improves group participant self-management capabilities, automates group participant check-ins, and identifies group members who may be at risk. Additional features on the platform allow providers to schedule and host virtual sessions, engage members in secure chat, and share health resources, and offer support groups

The Human Diagnosis Project (also referred to as “Human Dx” or “the Project”) is a worldwide effort to build an open medical intelligence system that maps the steps to help any patient. By combining collective intelligence with machine learning, Human Dx intends to enable more accurate, affordable, and accessible care for all

Out-of-pocket healthcare costs are skyrocketing and every day, people all across America are forced to make difficult decisions about their health. Lively is the benefits solutions provider that gets it right. We designed our solutions to take the guesswork out of managing benefits. And our innovative features are built to simplify benefits administration and evolve with your business. Managing wellness and wealth takes more than a series of transactions. By combining robust features with unparalleled service, we make benefits administration effortless, even when time and energy are limited. Experience benefits administration as it should be with Lively. Go to www.livelyme.com to learn about how HSAs other modern employee benefits can help you and your team.

Osmind is the premier platform for clinicians and researchers advancing new life-saving mental health treatments. Today, mental health disorders are one of the leading causes of death worldwide, especially among young adults, and are tied to shortening lifespans. While there have been developments in new psychiatric medications since the first FDA approval in 1954, today there is a growing movement among clinicians, patients, and researchers who are recognizing the need to accelerate new science. The Osmind treatment platform is the first and only solution that solves specific challenges faced by neuropsychiatric clinics, spanning general psychiatry and interventional psychiatry (transcranial magnetic stimulation, ketamine, SPRAVATO®, psychedelic medicine, electroconvulsive therapy). The core electronic health record (EHR) technology is precisely developed for interventional treatment workflows and designed to support a strong therapeutic alliance, including journaling tools and assistance with health plan reimbursement, which is a significant access hurdle for millions of patients. Research from our platform is already helping to set new standards for mental health interventions. For example, in the largest published real-world analysis of ketamine infusion therapy for depression, we teamed up with Stanford University School of Medicine to share findings in the Journal of Affective Disorders (March 2022). We have multiple ongoing research studies leveraging our proprietary real-world data, including an even larger ketamine analysis leveraging machine learning to predict treatment outcomes. Osmind is a San Francisco–based public benefit corporation led by scientists, technologists, and psychiatrists. We are backed by top investors including DFJ Growth, General Catalyst, Future Ventures, Tiger Global, and Y Combinator.

Our mission is simple: challenge archaic rules and implied medical conventions in healthcare to better serve patients and physicians. Gradia is the backbone of the entire patient experience, helping patients get personalized, high-touch care while also making clinics more money. With our software patients can stay informed/educated about the status of their care, easily communicate with their providers, and get direct access to a specialized virtual care team. Our software is currently at several clinics across the Southeastern US and helping thousands of patients get the care they deserve. 

Medplum makes it easy to build healthcare webapps that are compliant and interoperability ready. Our open source toolkit allows healthcare providers write apps that are HIPAA compliant, SOC2 certified and FHIR native - streamlining payor connections, health system integrations and more.

At AgileMD, we are building the most advanced real-time predictive analytics and clinical algorithms platform for hospitals. Our cloud-based engine helps thousands of doctors and nurses around the country make medical decisions, so that every patient receives the highest quality and value of care based on the latest medical knowledge and data.

We help healthcare companies run their practices. Eligibility, BI, claims, patient payments? Shoot us an email at founders@aperohealth.com Apero is a Y-Combinator-backed startup based in San Francisco bringing transparency and ease to medical billing. As one of the top startups from the Summer 2019 Y Combinator batch, we have raised from well-known investors including the creator of Gmail Paul Buchheit and the founders of Doctor on Demand, Gusto and Reddit, and serve startups that have raised over $1B in Venture Capital. The founding team are Stanford CS and Berkeley grads and include the CTO of Doctor on Demand having helped raised $240m and process millions of video calls. We are also hiring for engineers and product-minded operations people interested in giving price transparency to patients and providers. We serve practices nationwide, and integrate with leading EHRs as well.

We’re on a mission to leverage AI and voice technology to solve inefficiencies and revenue leakage in our healthcare system. With the rise of EHRs, the manual documentation burden on doctors has never been higher, leading to burnout and fatigue and high attrition rates. Assigning the correct diagnosis and billing codes is crucial for proper reimbursement and patient care, but medical coding is becoming more and more complex each year with growing numbers of codes (over 145,000 now), and doctors are unsupported by current technology to keep up with its ever increasing requirements. $125 billion is left on the table each year by healthcare organizations due to improper documentation and coding. Knowtex creates visit notes with up-to-date and accurate reimbursement codes from doctor-patient conversations, allowing the doctor to focus on patient care and preventing revenue leakage for hospital systems through standardized, transparent, and accurate documentation.

$1 T is spent today on back office tasks such as patient triaging, intake, eligibility checks, prior auths and claims. Specialized knowledge is required to complete these tasks making them prone to errors and bottlenecked by staffing. Lamar Health takes the burden off of providers and intelligently automates these tasks. Starting with specialty medications.

Blueberry Medical provides concierge pediatric care with at-home medical diagnostics and an always-available team of Pediatricians. Blueberry handles twice as may illnesses as any other telemedicine provider and has proven to reduce ER costs by 50%.

Healthcare is delivered by teams – nurses, doctors, and staff, specific to each hospital, clinic, and department. They want to do their best, but cannot keep up with constantly changing information. Burnout >50%. Unprecedented turnover. Growing medical errors (the #3 cause of death in the US). $100B+ in waste. Elemeno Health is a UCSF and Y Combinator-backed B2B SaaS for healthcare facilities– “a playbook in your pocket,” customized to support frontline teams with bite-sized training and communication at their fingertips, accessible 24/7 on any device. Our efficacy is demonstrated in our published results, passionate clients, and consistent renewals. 20x ROI. 75% decrease in medical errors.

The world’s No. 1 lab management platform. We help scientists easily organize orders, manage inventory, and save money.

Have you ever wondered why it's so hard for physicians to communicate quickly and why the leading cause of preventable death is still a delay in communication? Our team has built the solution for this. Medigram is a team of tier 1 health system CxO IT executives, technologists, SaaS exec, physicians, engineers, and data experts. We have developed a breakthrough service for the medical industry to save lives and for hospitals to make millions per year. Medigram instantly flags insights from clinician chats for immediate insight into hospital operations and patient care. This reduces critical response times by 50%. We've designed this system to provide instant, reliable messaging (including images and audio files) across very complicated network environments in hospitals. Medigram is secure, designed for HIPAA, and a full stack system which includes database back end, middleware, logic, and client apps for iOS, Android, desktop, and the web. Our solution to this is Mobile Intelligence For Healthcare by providing a secure, intelligent workflow management platform for the patient care ecosystem and medical professionals. Within the healthcare environment, you have physicians, the patient care team, EMR, workflow, data, and administration which needs to be tied together with intelligence through Medigram.

Enzyme provides online quality management system software and supportive QA/RA consulting, helping life science companies with FDA approval and ongoing compliance. Enzyme staff has over 50 years of medical device industry experience, across several Fortune 500 companies and startups.

One Codex is a data platform for applied microbial genomics, enabling new and valuable applications in clinical diagnostics, food safety, and biosecurity. Acquired by Invitae (NVTA) in February 2021. Spun out as an independent company in September 2022.

Memora Health helps healthcare organizations digitize and automate complex care workflows, making them simple for patients and clinicians to navigate. Memora ingests existing data on clinical workflows, converts them into cohesive messaging journeys that guide patients through their care episodes, and automates the completion of simple follow-up tasks in the EMR. Memora's platform reduces care team notifications by nearly 40%, has a >70 average NPS, and has improved clinical outcomes across various populations. Contact us at info@memorahealth.com

Kip combines traditional in-person therapy with a private app so that you get the most out of every session. Meet your therapist in person and start working on your personalized care plan. Share daily thoughts, feelings, and events with your therapist on Kip's private app. Achieve measurable results with Kip's science-backed, results-driven approach. Not your average therapy service, Kip makes therapy more effective by combining in-person visits with digital support in-between.

Waiting rooms suck. Insurance and the paperwork are worse. We are a team of doctors, developers, lawyers, designers, and more working to try to fix it. Using our app, and soon the website, you can access medical care online right now and be done in 5 minutes. No insurance, video, or phone calls necessary and most visits are under $20. You can chat with your doctor anytime and anywhere. Our services are currently available in Arizona, California, Connecticut, Florida, Georgia, Illinois, Montana, New York, Ohio, Pennsylvania, Rhode Island, Virginia and Washington, but don't worry the rest of the country coming soon. Here are the medical services we offer so far: - Acne Diagnosis, Treatment, and Prevention - High Cholesterol (Lipid) Testing and Treatment - Start or Refill Birth Control - Urinary Tract Infection (UTI) Testing and Treatment - Vitamin D Screening and Treatment - Pre-Diabetes Screening and Referral - Hepatitis C Screening and Referral - Female Condom Prescription - Help Quitting Smoking - Find Out Your Blood Type We are adding new services every week, so if you don't see what you need let us know. We want HeyDoctor and our partner health systems to be your first stop for healthcare and be your personal medical record.

Onederful is an API for dental insurance. Automate verifications and claim submissions across 200+ dental insurance carriers.

MedXT is the easiest way to manage medical images online. We make it easy for medical professionals to access and share their medical data safely and securely. We provide specialty tools such as RIS, PACS, and HL7 connectivity. The MedXT platform will power your imaging center, hospital radiology department, or radiology group. Learn more at https://www.medxt.com

Formerly known as Patchd Medical, now acquired by Cytovale. Wearable technology and AI to predict and prevent sepsis outside of hospital.

Able Health is the one platform physician organizations need to manage value-based programs. From calculating HEDIS and Medicare measures to engaging clinicians and health plans, managing value-based programs can take an army of administrators and IT staff. Able Health simplifies administration, customized to your specific programs, so you can ease today's reporting requirements and set your organization up for the future of healthcare reimbursements.

Listrunner is a service made to share patient information in a highly secure manner between authorized members of a clinical team– physicians, residents, interns, and medical students. Listrunner helps clinicians protect patient information by replacing manual processes, such as printed patient lists, which are untraceable and easily lost. Listrunner offers a secure alternative to unsecure practices, such as the use of SMS messages and camera phones to collect and share patient information between clinicians.

Our API-connected healthcare infrastructure empowers our partners to deliver world-class patient experiences. We power prescribing, lab testing and pharmacy fulfillment.

Comprehend, the leader in Clinical Intelligence solutions, is focused on accelerating treatments to patients. Our suite of software applications provide clinical operations, data management and medical review teams with the critical insights and automation they need to improve the speed, safety and quality of their clinical trials. Designed to unify, monitor and analyze clinical data across disparate sources in real-time, Comprehend's Cloud software delivers solutions for CRO oversight, centralized monitoring, risk monitoring, data review and medical monitoring. Comprehend’s investors include Sequoia Capital, Lightspeed Venture Partners and Eminence Capital. Learn more at www.comprehend.com.