Healthcare Startups funded by Y Combinator (YC) in the San Francisco Bay Area that are currently hiring 2025

March 2025

Browse 37 of the top Healthcare startups funded by Y Combinator. Headquartered in the San Francisco Bay Area, these are some of the hottest and fastest-growing startups. Their teams are well-funded and actively hiring.

We also have a Startup Directory where you can search through over 5,000 companies.

  • Notable Labs
    Notable Labs
    Y Combinator LogoW2015
    Public • 40 employees • Foster City, CA, USA
    Notable Labs is building a personalized drug discovery platform to identify treatment options for relapsed and refractory cancer patients — starting with blood cancer — to address the long tail of cancer treatment. We look at a person’s actual cancer cells, test combinations of FDA approved drugs, and see which combinations kill the cancer cells and leave the healthy cells alive. We focus on combinations because cancer is often difficult to target with just one drug and starting with a single drug can lead to resistant clones or relapse. We're building a highly automated lab in Foster City running on our custom software and are currently testing relapsed/refractory cancer patients as well as samples from a variety of pharma/biotech partnerships. https://www.notablelabs.com/careers
    biotech
    drug-discovery
    oncology
  • Modern Fertility
    Modern Fertility
    Y Combinator LogoS2017
    Acquired • 25 employees • San Francisco, CA, USA
    We're a women’s health company making personalized reproductive health information more accessible, earlier in life. We make the same laboratory tests that were previously confined to fertility clinics more accessible for women at home. By arming women with powerful information about their reproductive health, Modern Fertility is closing the fertility information gap and enabling women to own the decisions impacting their bodies and futures. We've raised $22 million from Forerunner Ventures, Maveron, Union Square Ventures, First Round Capital, #Angels and Y Combinator.
    fertility-tech
    consumer-health-services
    women's-health
  • AgileMD
    AgileMD
    Y Combinator LogoS2011
    Active • 15 employees • San Francisco, CA, USA
    At AgileMD, we are building the most advanced real-time predictive analytics and clinical algorithms platform for hospitals. Our cloud-based engine helps thousands of doctors and nurses around the country make medical decisions, so that every patient receives the highest quality and value of care based on the latest medical knowledge and data.
    machine-learning
    healthcare
  • SimplyInsured
    SimplyInsured
    Y Combinator LogoW2013
    Active • 35 employees • San Francisco, CA, USA
    SimplyInsured was founded with one mission: to eliminate fear from health insurance. By changing the way small business owners purchase health insurance with our 100% online platform, we’re transforming a $20 billion dollar industry and delighting thousands of customers. Our unique values-based culture (and extremely talented team) is our core competitive advantage, and each person on our team makes a direct, immediate impact on our business. We value transparency, feedback, bias to action, growth, and an obligation to dissent. Every opinion is respected, we hold each other to extremely high standards, we’re driven by the diversity in our backgrounds, and unified by 100% alignment on our mission. What’s best for the customer is the heart of everything we do, and our customer stories prove it: by changing health insurance we’re literally saving lives. Based in San Francisco, SimplyInsured was founded in 2012 and is back by Bessemer Venture Partners, Polaris Ventures, and Y-Combinator. If you’re up for the challenge of improving health insurance for millions of Americans, we’re just getting started, and we’re growing!
    health-insurance
  • PicnicHealth
    PicnicHealth
    Y Combinator LogoS2014
    Active • 100 employees • San Francisco, CA, USA
    Healthcare needs good data. At PicnicHealth, we are building deep real-world datasets fueling cutting-edge research while giving patients control of their own medical record data. These complete, clinically-rich datasets produce unique insights — across dozens of diseases — to ultimately get the right treatments into patients’ hands faster. We work directly with patients and leverage state of the art machine learning to transform messy medical records into structured, research-ready datasets. To date we’ve helped tens of thousands of patients securely access their records and proactively contribute to advancing research in diseases that impacts their lives.
    machine-learning
    health-tech
    digital-health
    healthcare
    nlp
  • Tempo
    Tempo
    Y Combinator LogoW2015
    Active • 158 employees • San Francisco, CA, USA
    SmartSpot is a post Series-A stealth startup backed by Founders Fund and Khosla Ventures that uses computer vision to deliver an unparalleled fitness training experience to your home. Our unique hardware solution gives amazing trainers the ability to see their class participants in real time and deliver detailed advice that was previously only possible in person.
    machine-learning
    consumer-health-services
  • NimbleRx
    NimbleRx
    Y Combinator LogoW2015
    Active • 130 employees • Redwood City, CA, USA
    We enable people to live their best lives. As we succeed, there is more convenience, healthier communities and thriving businesses. We get medications to those who need them and improve information, access and management of their care and enable businesses to move online and gain access to consumers who need their services
    saas
  • Circle Medical
    Circle Medical
    Y Combinator LogoS2015
    Active • 153 employees • San Francisco, CA, USA
    Circle Medical is a venture-backed Y-Combinator healthcare startup on a mission to bring quality, delightful primary care to everyone on the planet. Built by top-tier physicians, engineers, and designers, our medical practice and underlying technology have pioneered how people find and receive care. Our focus on building directly for our patients and providers to address serious care accessibility issues has enabled us to grow over 3X year-over-year. We’re now using our most recent round of funding from WELL Health, backed by Sir Li Ka-shing, to continue building out our hybrid in-clinic and telemedicine model across all fifty states. As we enter the hypergrowth phase, we are looking for deeply motivated team players who are driven to solve some of the biggest challenges in healthcare so that people can live longer and healthier lives. More about us can be found on our website!
    consumer-health-services
    primary-care
  • iSono Health
    iSono Health
    Y Combinator LogoW2016
    Active • 9 employees • San Francisco, CA, USA
    The iSono Health platform combines automated 3D ultrasound technology with cloud computation and artificial intelligence to empower women and their physicians with early detection and monitoring of breast cancer. Our patented compact ultrasound scanner captures 3D images through automatic scanning of whole breast volume in 1 min. The device connects to a smartphone/tablet/laptop and is controlled by our mobile app. The data is transferred to a secure cloud for image processing and storage. Our machine learning algorithm uses acoustic biomarkers to identify abnormal masses. Our platform’s automated operation and software expands ultrasound use in point-of-care diagnostics as well as monitoring of breast health at home, walk-in and mobile clinics. iSono Health offers women and healthcare providers : Safety: No Radiation Actionable Feedback with AI Fast: 2min Scan Easy to Use
    artificial-intelligence
    consumer-health-services
    medical-devices
  • BillionToOne
    BillionToOne
    Y Combinator LogoS2017
    Active • 300 employees • Menlo Park, CA, USA
    BillionToOne has developed a DNA molecular counter that increases the cell-free DNA diagnostics resolution by over 1,000 fold, which unlocks transformative improvements in prenatal screening and liquid biopsy for cancers. Unity Screen, BillionToOne's commercially available non-invasive prenatal test (NIPT), is the only NIPT that can assess fetal risk for both recessive conditions and aneuploidies from maternal blood. UNITY Screen continues to grow exponentially and is on its path to becoming the next standard-of-care, with an increasing number of publications showing its accuracy and advantages over other screening methods. We have also recently used our molecular counting technology to develop liquid biopsy tests, which have the potential to completely transform oncology care.
    diagnostics
    genomics
  • Sleep Reset
    Sleep Reset
    Y Combinator LogoW2017
    Active • 8 employees • San Francisco, CA, USA
    Our mission is to improve quality of life for millions of people by providing easy, immediate access to the world’s best sleep care. Sleep Reset is a digital, personalized sleep clinic, available in a convenient mobile app for iOS and Android. Our program was designed in partnership with leading sleep experts from top sleep clinics and universities. The program improves sleep and reduces sleep anxiety with the most effective methods from sleep clinics, including strategies based on Cognitive Behavioral Therapy for Insomnia (CBT-i) which are proven to be more effective than sleeping pills. Throughout our program, each member is paired with a dedicated sleep coach who personalizes their program. It’s a life-long, sustainable solution to sleep better in weeks, with no pills or melatonin needed – which means no grogginess, side effects, or dependency. Sleep Reset has been covered in Forbes, TechCrunch, and INSIDER. The company was founded by Yunha Kim, a serial entrepreneur recognized by Forbes as 30 Under 30 and is backed by top Silicon Valley investors including YCombinator, Foundation Capital, New Enterprise Associates, Stanford University and 20+ founders/executives of leading companies.
    mental-health-tech
    sleep-tech
    consumer-health-services
    health-tech
    digital-health
  • Lively, Inc.
    Lively, Inc.
    Y Combinator LogoW2017
    Active • 195 employees • San Francisco, CA, USA
    Out-of-pocket healthcare costs are skyrocketing and every day, people all across America are forced to make difficult decisions about their health. Lively is the benefits solutions provider that gets it right. We designed our solutions to take the guesswork out of managing benefits. And our innovative features are built to simplify benefits administration and evolve with your business. Managing wellness and wealth takes more than a series of transactions. By combining robust features with unparalleled service, we make benefits administration effortless, even when time and energy are limited. Experience benefits administration as it should be with Lively. Go to www.livelyme.com to learn about how HSAs other modern employee benefits can help you and your team.
    fintech
    health-tech
    hr-tech
  • Rev Genomics
    Y Combinator LogoS2017
    Active • 8 employees • Oakland, CA, USA
    Rev Genomics is a plant biotechnology company that provides breeders, growers, and retailers with novel cultivars to differentiate themselves in high value markets.
    b2b
  • Blueberry Pediatrics
    Blueberry Pediatrics
    Y Combinator LogoW2018
    Active • 15 employees • Mountain View, CA, USA
    Blueberry Medical provides concierge pediatric care with at-home medical diagnostics and an always-available team of Pediatricians. Blueberry handles twice as may illnesses as any other telemedicine provider and has proven to reduce ER costs by 50%.
    consumer-health-services
    health-tech
    telehealth
    pediatrics
    digital-health
  • Modern Health
    Modern Health
    Y Combinator LogoW2018
    Active • 375 employees • San Francisco, CA, USA
    Modern Health is the leading mental wellness platform that combines clinically validated assessments, personalized stress management support, an international network of certified behavioral health coaches, and licensed therapists to deliver mental health support across a broad range of individual needs. Modern Health empowers employers to lead the charge in helping their employees be less stressed, more engaged, and happier through evidence-based technology and professional support. Modern Health has raised over $170M from top investors Battery Ventures, Kleiner Perkins, Founders Fund, and John Doerr and supports over 200 companies globally including Lyft, Pixar, SoFi, Credit Karma, Electronic Arts, Cooley, and Okta.
    mental-health-tech
    health-tech
  • Bunkerhill Health
    Bunkerhill Health
    Y Combinator LogoW2019
    Active • 30 employees • San Francisco, CA, USA
    Bunkerhill is a Sequoia/Felicis/YC-backed company whose goal is to increase the adoption of AI in healthcare, in order to help doctors catch deadly diseases earlier. Bunkerhill Health has built a consortium of research institutions (Stanford, Johns Hopkins, Harvard, etc.), who develop and validate AI algorithms seamlessly under our legal umbrella (less than one week of setup time for a new project when using the Bunkerhill consortium, versus a year or more for projects outside the consortium). Bunkerhill then manages the FDA clearance and commercial sales process for the algorithms that these institutions develop and validate with us. We’ve signed commercial contracts and deployed algorithms with the world’s leading health systems—UCSF, Mayo Clinic, Georgetown/MedStar, and several others. These algorithms help doctors identify patients earlier than has otherwise been possible, leading to better treatment outcomes (early clinical screening for heart disease, pancreatic cancer, etc.) We’re backed by world class investors: Sequoia, Felicis, SVAngel, Optum Ventures, Max Levchin (co-founder of PayPal and Affirm), YC, DCVC, and Pacific8.
    marketplace
    healthcare-it
    ai
  • Apero Health
    Apero Health
    Y Combinator LogoS2019
    Active • 24 employees • San Francisco, CA, USA
    We help healthcare companies run their practices. Eligibility, BI, claims, patient payments? Shoot us an email at founders@aperohealth.com Apero is a Y-Combinator-backed startup based in San Francisco bringing transparency and ease to medical billing. As one of the top startups from the Summer 2019 Y Combinator batch, we have raised from well-known investors including the creator of Gmail Paul Buchheit and the founders of Doctor on Demand, Gusto and Reddit, and serve startups that have raised over $1B in Venture Capital. The founding team are Stanford CS and Berkeley grads and include the CTO of Doctor on Demand having helped raised $240m and process millions of video calls. We are also hiring for engineers and product-minded operations people interested in giving price transparency to patients and providers. We serve practices nationwide, and integrate with leading EHRs as well.
    health-tech
    finance
    digital-health
    enterprise-software
  • Fella Health
    Fella Health
    Y Combinator LogoW2020
    Active • 4 employees • San Francisco, CA, USA
    Fella Health is the telehealth clinic for men with obesity. With Fella, patients meet a board-certified obesity doctor to prescribe FDA-approved medications, while they undertake personalized health coaching through our app.
    consumer-health-services
    healthcare
    telemedicine
  • Daybreak Health
    Daybreak Health
    Y Combinator LogoS2020
    Active • 20 employees • San Francisco, CA, USA
    Daybreak offers comprehensive and clinically-validated online mental health services designed for youth, like teletherapy, psychiatry and digital education. We partner with schools and pediatric groups to make access to services easy, and strive to deliver zero cost to the end consumer through insurance and government funding.
    mental-health-tech
    consumer-health-services
    digital-health
  • Gradia Health
    Gradia Health
    Y Combinator LogoW2021
    Active • 7 employees • San Francisco, CA, USA
    Our mission is simple: challenge archaic rules and implied medical conventions in healthcare to better serve patients and physicians. Gradia is the backbone of the entire patient experience, helping patients get personalized, high-touch care while also making clinics more money. With our software patients can stay informed/educated about the status of their care, easily communicate with their providers, and get direct access to a specialized virtual care team. Our software is currently at several clinics across the Southeastern US and helping thousands of patients get the care they deserve. 
    consumer-health-services
    health-tech
    telehealth
    digital-health
    healthcare
  • Auricle
    Auricle
    Y Combinator LogoW2021
    Active • 2 employees • Mountain View, CA, USA
    Auricle is a medical device company building a breakthrough neurostimulation implant to restore hearing in millions of patients who no longer benefit from hearing aids, get less than 60% on a word recognition test, but aren't prepared to make the jump to a cochlear implant. Our approach preserves remaining natural hearing through a reversible and less invasive surgery, addressing the key concerns that hold most patients back from getting a cochlear implant (currently the only treatment option for these patients). The company spun out of Stanford Biodesign having completed two acute human clinical studies demonstrating the approach will work. The team is now focused on developing their full implant system for their first clinical trial. Auricle addresses a currently unserved profile of hearing loss that affects a growing population of 3.5 million patients in the US and represents an immediately accessible $1.2B market opportunity with existing reimbursement.
    hard-tech
    neurotechnology
    health-tech
    medical-devices
    healthcare
  • Triomics
    Triomics
    Y Combinator LogoW2021
    Active • 50 employees • San Francisco, CA, USA
    Triomics is helping cancer care providers by reducing the burden associated with manually reviewing patient charts. Utilizing our OncoLLM™—a family of oncology-focused language models—we are able to accelerate clinical trial enrollment, power quality improvement projects, and address many other key strategic priorities.
    healthcare
  • SafeBeat
    SafeBeat
    Y Combinator LogoS2021
    Active • 9 employees • San Francisco, CA, USA
    38 million people suffer from heart rhythm disorders and are recommended to start medications that can save their lives, but require rigorous ECG monitoring to start and remain on these pills. SafeBeat Rx moves beyond diagnostics to guide these therapeutics, powered by our ML ECG software that integrates with existing FDA-cleared wearables to allow seamless physician approval of drug dosing, all from a mobile phone. We are a team of physicians, engineers, data scientists, and machine learning experts dedicated to using engineering to improve heart health.
    ai-enhanced-learning
    medical-devices
    therapeutics
  • Rinse
    Rinse
    Y Combinator LogoS2021
    Active • 6 employees • San Francisco, CA, USA
    Rinse is building the One Medical for dental. Beautiful studios, easy to book same day appointments, and anxiety-free care focused on prevention, not the upsell.
    consumer-health-services
    digital-health
    telemedicine
    primary-care
  • Invert
    Invert
    Y Combinator LogoW2022
    Active • 25 employees • San Francisco, CA, USA
    We build software to manage, analyze, and optimize bioprocessing data. Our initial customers are bio-industrial companies, who produce various products in bioreactors.
    cellular-agriculture
    machine-learning
    synthetic-biology
    biotech
  • Ankr Health
    Ankr Health
    Y Combinator LogoW2022
    Active • 30 employees • San Francisco, CA, USA
    Adoption of Telehealth 1.0 has dropped to <5% because it's inefficient and unintelligent. Ankr uses generative AI to recreate functions of clinic staff including front desk, medical assistants and scribe. This allows Doctors to "spin-up" virtual clinics on-demand, anytime, anywhere. An average clinic using Ankr generates $1M in new revenue/year. We integrate with all top EHRs and work with all types of clinics in mid- to large-sized healthcare organizations.
    generative-ai
    telehealth
    b2b
    digital-health
    telemedicine
  • Joon Health
    Joon Health
    Y Combinator LogoW2022
    Active • 10 employees • San Francisco, CA, USA
    Joon is an integrated pediatric digital health platform for kids, starting with behavior disorders like ADHD, autism, anxiety, and depression. In Joon, kids access a game-based digital therapeutic where they level up when they do real-life behaviors that are managed by parents and clinicians. Over the next 10 years, we plan on being the first-line vertically integrated digital treatment for pediatric behavior disorders, leveraging the first of its kind technology to drive behavior change.
    mental-health-tech
    consumer-health-services
    consumer
  • Medplum
    Medplum
    Y Combinator LogoS2022
    Active • 3 employees • San Francisco, CA, USA
    Medplum makes it easy to build healthcare webapps that are compliant and interoperability ready. Our open source toolkit allows healthcare providers write apps that are HIPAA compliant, SOC2 certified and FHIR native - streamlining payor connections, health system integrations and more.
    developer-tools
    open-source
    healthcare
  • Knowtex
    Knowtex
    Y Combinator LogoS2022
    Active • San Francisco, CA, USA
    We’re on a mission to leverage AI and voice technology to solve inefficiencies and revenue leakage in our healthcare system. With the rise of EHRs, the manual documentation burden on doctors has never been higher, leading to burnout and fatigue and high attrition rates. Assigning the correct diagnosis and billing codes is crucial for proper reimbursement and patient care, but medical coding is becoming more and more complex each year with growing numbers of codes (over 145,000 now), and doctors are unsupported by current technology to keep up with its ever increasing requirements. $125 billion is left on the table each year by healthcare organizations due to improper documentation and coding. Knowtex creates visit notes with up-to-date and accurate reimbursement codes from doctor-patient conversations, allowing the doctor to focus on patient care and preventing revenue leakage for hospital systems through standardized, transparent, and accurate documentation.
    health-tech
    b2b
    productivity
    digital-health
    ai
  • Orchid
    Orchid
    Y Combinator LogoW2023
    Active • 4 employees • San Francisco, CA, USA
    Orchid is an AI-powered Electronic Health Record (EHR) for independent mental health professionals that saves them time, money, and frustration by integrating core administrative workflows, streamlining clinical processes, and automating manual flows.
    artificial-intelligence
    mental-health-tech
    saas
    health-tech
    healthcare
  • One Codex
    One Codex
    Y Combinator LogoS2014
    Acquired • 16 employees • San Francisco, CA, USA
    One Codex is a data platform for applied microbial genomics, enabling new and valuable applications in clinical diagnostics, food safety, and biosecurity. Acquired by Invitae (NVTA) in February 2021. Spun out as an independent company in September 2022.
    biotech
    diagnostics
    genomics
  • Loop Genomics
    Y Combinator LogoW2016
    Acquired • 7 employees • San Jose, CA, USA
    Loop Genomics provides long-read sequencing solutions across a diverse set of research and clinical applications. Our platform for long-read DNA sequencing transforms short-read DNA sequencers into long-read sequencing machines.
    biotech
  • Able Health
    Y Combinator LogoW2016
    Acquired • 11 employees • San Francisco, CA, USA
    Able Health is the one platform physician organizations need to manage value-based programs. From calculating HEDIS and Medicare measures to engaging clinicians and health plans, managing value-based programs can take an army of administrators and IT staff. Able Health simplifies administration, customized to your specific programs, so you can ease today's reporting requirements and set your organization up for the future of healthcare reimbursements.
  • Clear Genetics
    Clear Genetics
    Y Combinator LogoW2017
    Acquired • 8 employees • San Francisco, CA, USA
    Clear Genetics is developing innovative, patient-centric software to thoughtfully integrate genetics into routine patient care. Our HIPAA-compliant platform offers an automated and comprehensive solution to deliver genetic services at scale. Clear Genetics serves leading health systems, clinics and commercial labs across the nation.
    healthcare
    chatbots
  • HeyDoctor
    HeyDoctor
    Y Combinator LogoS2018
    Acquired • 50 employees • San Francisco, CA, USA
    Waiting rooms suck. Insurance and the paperwork are worse. We are a team of doctors, developers, lawyers, designers, and more working to try to fix it. Using our app, and soon the website, you can access medical care online right now and be done in 5 minutes. No insurance, video, or phone calls necessary and most visits are under $20. You can chat with your doctor anytime and anywhere. Our services are currently available in Arizona, California, Connecticut, Florida, Georgia, Illinois, Montana, New York, Ohio, Pennsylvania, Rhode Island, Virginia and Washington, but don't worry the rest of the country coming soon. Here are the medical services we offer so far: - Acne Diagnosis, Treatment, and Prevention - High Cholesterol (Lipid) Testing and Treatment - Start or Refill Birth Control - Urinary Tract Infection (UTI) Testing and Treatment - Vitamin D Screening and Treatment - Pre-Diabetes Screening and Referral - Hepatitis C Screening and Referral - Female Condom Prescription - Help Quitting Smoking - Find Out Your Blood Type We are adding new services every week, so if you don't see what you need let us know. We want HeyDoctor and our partner health systems to be your first stop for healthcare and be your personal medical record.
    telehealth
    digital-health
    primary-care